EGFR基因检测,可选择支气管镜下冷冻活检取样

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  冷冻活检提高非小细胞肺癌EGFR检测率
  结论
  与其他组织取样技术相比,支气管镜下冷冻活检提高了非小细胞肺癌中EGFR突变的检出率。
  这将有助于优化晚期肿瘤患者的个体化治疗。由于本分析的回顾性性质,最终评估结果必须进行前瞻性试验。
  Bronchosopic cryobiopsy increases the detection rate of activating EGFR mutations in NSCLC in comparison to other tissue sampling techniques. This will help to optimize individualized treatment of patients with advanced tumors. Because of the retrospective nature of this analysis, a prospective trial is mandatory for final assessment
  目的
  活化表皮生长因子受体(EGFR)突变的检测对晚期非小细胞肺癌(NSCLC)的个体化治疗至关重要。
  然而,目前对活检技术如何影响EGFR突变的检出率知之甚少。
  这项回顾性的单中心研究评估了经支气管镜冷冻活检获得的组织中EGFR突变的检出率,并与其他标准组织取样技术进行了比较。
  Detection of activating epidermal growth factor receptor (EGFR) mutation is crucial for individualized treatment of advanced non-small-cell lung cancer (NSCLC). However little is known about how biopsy technique affects the detection rate of EGFR mutations. This retrospective, single center study evaluated the detection rate of EGFR mutations in tissue obtained by bronchoscopic cryobiopsy and compared this to other standard tissue sampling techniques.
  材料和方法
  我们回顾性分析了2008年3月至2014年7月期间414例组织学确诊的非小细胞肺癌患者和已知的EGFR突变情况。
  将经组织保存的支气管镜冷冻活检获得的肿瘤标本与其他技术获得的标本进行比较。
  We retrospectively analyzed 414 patients with histologically confirmed NSCLC and known EGFR mutation status between 3/2008-7/2014. Tumor specimens obtained by tissue preserving bronchoscopic cryobiopsy were compared to those obtained by other techniques.
  结果
  对125例患者中27例(21.6%)的支气管镜下冷冻活检组织进行分析,发现29个EGFR突变,而对非冷冻活检技术(支气管镜钳活检、细针抽吸、支气管镜活检、支气管镜活检、支气管镜活检)获得的组织进行分析,在298例患者中,40例(13.8%)检测到42个EGFR突变(p<0.05)。
  与钳夹活检相比,冷冻活检提高了中心肿瘤EGFR突变的检出率(19.6%对6.5%,p <0.05),而外周肿瘤EGFR突变的检出率(33.3%对26.9%)也无明显变化。
  Analysis of bronchoscopic cryobiopsy tissue detected 29 activating EGFR mutations in 27 (21.6%) out of 125 patients, while analysis of tissue obtained by non-cryobiopsy techniques (bronchoscopic forceps biopsies, fine needle aspiration, imaging guided transthoracical and surgical procedures) detected 42 EGFR mutations in 40 (13.8%) out of 298 patients (p < 0.05). Cryobiopsy increased detection rate of EGFR mutations in central tumors compared with forceps biopsy (19.6% versus 6.5%, p < 0.05), while an insignificant trend was detected also for peripheral tumors (33.3% versus 26.9%).
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