EBV阳性黏膜皮肤溃疡的病理特征包含9例病例的研究

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  --本文经《美国外科病理学杂志》授权发布,其他媒体转载或引用须经《美国外科病理学杂志》同意,否则追究法律责任。
  本文分析了9例EB病毒(Epstein-Barrvirus,EBV)阳性黏膜皮肤淋巴组织增生性病变的病理特征,这拓展了EBV阳性黏膜皮肤溃疡的概念。9例病例中有女性5例和男性4例,平均年龄74岁(范围,55~87岁),其中2例为HIV阳性患者。病变位于口咽、皮肤、直肠和生殖器黏膜。组织病理学上,6例显示出多形性以及3例表现为单形性和弥漫性,4例表现出血管改变(具有多形性和单形性模式各2例)。其中3例表达PDL1。除了在肿瘤性淋巴细胞中表达外,在1例口咽部病变的相邻黏膜上皮细胞中同样检测到了EBV。9例病例在进行了局部治疗或系统性化疗后,病变均有改善或消退。本文通过对9例病例的分析,
  扩展了EBV阳性黏膜皮肤溃疡的疾病谱系,包括HIV阳性病例、局限于单一解剖区域的多处病灶、具有血管中心性病变模式以及一些具有单一大细胞形态的病例。本文同时讨论了EBV阳性黏膜皮肤溃疡与经典EBV阳性大B细胞淋巴瘤的不同临床病理诊断特征。
  Am J Surg Pathol 2019;43:187-194
  美国外科病理学杂志中文版2019年第三期摘要NO.2
  (任华艳 翻译 李晟磊 审校)
  The American Journal of Surgical Pathology中文版声明:
  ©2018 Wolters Kluwer Health
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