浅表性孤立性纤维性肿瘤——26例病例系列报道

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  尽管浅表性(皮肤/皮下)孤立性纤维性肿瘤(solitary fibrous tumor,SFT)已有报道,但因其与其他肿瘤存在形态学重叠准确诊断仍十分困难。我们报道了迄今为止最大宗系列的浅表性SFT病例。纳入标准为SFT出现在真皮或皮下组织中。共确定26例病例。患者年龄范围为16~80岁(平均,47岁),女性明显居多(19例女性;7例男性)。肿瘤位于头(11例)、大腿(7例),背部(3例)、肩部(2例)、上臂(1例)、踝部(1例)和大拇趾(1例)。肿瘤平均大小为2.9cm(范围,1.0~7.0cm)。大多数病例(19例)具有典型的组织学特征(富于细胞性SFT)伴不规则梭形细胞束、鹿角样血管以及不等的胶原纤维。3例见明显坏死(全部<25%)。核分裂计数0~10个/10HPF(平均,2个/10HPF)。18例中有17例STAT6阳性,22例中有21例CD34阳性。参照Demicco及其同事提出的标准,所有病例〔23/23)均为低危险度,包括2例显示恶性形态学病例。3例因缺乏肿瘤大小数据不能进行危险
  度评估。7例具有随访资料(平均随访时间,100个月:范围,2~241个月)患者均未见复发/转移。皮肤SFT更常见于女性,好发于头部。尽管需要更大宗病例研究的进一步证实,但根据现有标准,浅表性SFT通常为低危险度,表现惰性生物学行为。认识到SFT可以表现为浅表肿块,这会避免将其错误地归类为皮肤和皮下组织中经常出现的其他CD34阳性肿瘤。
Am J Surg Pathol 2018;42:778-785
美国外科病理学杂志中文版2019年第一期摘要No.1
任俊奇 翻译 朱朋成 审校
  The American Journal of Surgical Pathology中文版声明:
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