类似甲状腺高细胞亚型乳头状肿瘤的乳腺实性乳头状癌:一种独特的具有惰性生物学行为的浸润性肿瘤

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  ——本文经《美国外科病理学杂志》授权发布,其他媒体转载或引用须经《美国外科病理学杂志》同意,否则追究法律责任。
 
  摘要
  本文报道了13例类似甲状腺高细胞亚型乳头状肿瘤的乳腺浸润性实性乳头状癌(breast tumors resembling the tall cell variant of papillary thyroid carcinoma,BPTC)。部分病例长期随访。BPTC是一种低侵袭潜能的特殊类型原发性三阴性乳腺癌。由于对BPTC了解甚少,本文旨在探讨13例BPTC患者的临床病理特征。13例患者均为女性,发病时平均年龄62.6岁;结节大小0.6到2.5cm(平均1.6cm)。组织学以乳头状、滤泡状和实性结构为特征。瘤细胞呈柱状,多数胞浆呈嗜酸颗粒状,富含线粒体,7例以上含有嗜酸细胞特征。雌激素受体(estrogen receptor,ER)、孕激素受体(progesterone receptor,PR)及人表皮生长因子受体2(human epidermal growth factor receptor 2,HER2)均阴性。Ki67增殖指数较低。甲状腺特异性标记物,如甲状腺转录因子1(Thyroid transcription factor 1,TTF1)和甲状腺球蛋白(thyroglobulin,Tg)为阴性。5例标记了乳球蛋白和GATA 3均阳性。所有病例均为浸润性,其中2例分别转移至1处淋巴结(腋窝和乳腺内),后者出现局部复发。所有患者术后随访24~132月均无瘤存活,其中8例除手术切除外未行进一步治疗。本研究证实BPTC是具有低度恶性潜能的原发性乳腺肿瘤。
  关键词
  乳腺、甲状腺样癌、乳头状癌
类似甲状腺高细胞亚型乳头状肿瘤的乳腺实性乳头状癌:一种独特的具有惰性生物学行为的浸润性肿瘤
类似甲状腺高细胞亚型乳头状肿瘤的乳腺实性乳头状癌:一种独特的具有惰性生物学行为的浸润性肿瘤
类似甲状腺高细胞亚型乳头状肿瘤的乳腺实性乳头状癌:一种独特的具有惰性生物学行为的浸润性肿瘤
类似甲状腺高细胞亚型乳头状肿瘤的乳腺实性乳头状癌:一种独特的具有惰性生物学行为的浸润性肿瘤
类似甲状腺高细胞亚型乳头状肿瘤的乳腺实性乳头状癌:一种独特的具有惰性生物学行为的浸润性肿瘤
类似甲状腺高细胞亚型乳头状肿瘤的乳腺实性乳头状癌:一种独特的具有惰性生物学行为的浸润性肿瘤
类似甲状腺高细胞亚型乳头状肿瘤的乳腺实性乳头状癌:一种独特的具有惰性生物学行为的浸润性肿瘤
类似甲状腺高细胞亚型乳头状肿瘤的乳腺实性乳头状癌:一种独特的具有惰性生物学行为的浸润性肿瘤
  来源:Am J Surg Pathol 2017;41:887–895
  美国外科病理学杂志中文版2017年第一期全文No.4
  (潘敏鸿/朱芸  翻译;张智弘 审校)
 
  The American Journal of Surgical Pathology 中文版声明:
  2017 American Journal of Surgical Pathology and Wolters Kluwer Health
  The material is published by Wolters Kluwer Health with the permission of American Journal of Surgical Pathology.No part of this publication may be reproduced in any form,stored in a retrieval system or transmitted in any form,by any means,without prior written permission from Wolters Kluwer Health.Opinions expressed by the authors and advertisers are not necessarily those of the American Journal of Surgical Pathology, its affiliates,or of the Publisher.The American Journal of Surgical Pathology,its affiliates,and the Publisher disclaim any liability to any party for the accuracy,completeness,efficacy,or availability of the material contained in this publication (including drug dosages) or for any damages arising out of the use or non-use of any of the material contained in this publication.
  Although advertising material is expected to conform to ethical (medical) standards,inclusion in this publication does not constitute a guarantee or endorsement of the quality or value of such product or of the claims made of it by its manufacturer
 
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