类似甲状腺高细胞亚型乳头状肿瘤的乳腺实性乳头状癌:一种独特的具有惰性生物学行为的浸润性肿瘤
  ——本文经《美国外科病理学杂志》授权发布,其他媒体转载或引用须经《美国外科病理学杂志》同意,否则追究法律责任。
 
  摘要
  本文报道了13例类似甲状腺高细胞亚型乳头状肿瘤的乳腺浸润性实性乳头状癌(breast tumors resembling the tall cell variant of papillary thyroid carcinoma,BPTC)。部分病例长期随访。BPTC是一种低侵袭潜能的特殊类型原发性三阴性乳腺癌。由于对BPTC了解甚少,本文旨在探讨13例BPTC患者的临床病理特征。13例患者均为女性,发病时平均年龄62.6岁;结节大小0.6到2.5cm(平均1.6cm)。组织学以乳头状、滤泡状和实性结构为特征。瘤细胞呈柱状,多数胞浆呈嗜酸颗粒状,富含线粒体,7例以上含有嗜酸细胞特征。雌激素受体(estrogen receptor,ER)、孕激素受体(progesterone receptor,PR)及人表皮生长因子受体2(human epidermal growth factor receptor 2,HER2)均阴性。Ki67增殖指数较低。甲状腺特异性标记物,如甲状腺转录因子1(Thyroid transcription factor 1,TTF1)和甲状腺球蛋白(thyroglobulin,Tg)为阴性。5例标记了乳球蛋白和GATA 3均阳性。所有病例均为浸润性,其中2例分别转移至1处淋巴结(腋窝和乳腺内),后者出现局部复发。所有患者术后随访24~132月均无瘤存活,其中8例除手术切除外未行进一步治疗。本研究证实BPTC是具有低度恶性潜能的原发性乳腺肿瘤。
  关键词
  乳腺、甲状腺样癌、乳头状癌
类似甲状腺高细胞亚型乳头状肿瘤的乳腺实性乳头状癌:一种独特的具有惰性生物学行为的浸润性肿瘤
类似甲状腺高细胞亚型乳头状肿瘤的乳腺实性乳头状癌:一种独特的具有惰性生物学行为的浸润性肿瘤
类似甲状腺高细胞亚型乳头状肿瘤的乳腺实性乳头状癌:一种独特的具有惰性生物学行为的浸润性肿瘤
类似甲状腺高细胞亚型乳头状肿瘤的乳腺实性乳头状癌:一种独特的具有惰性生物学行为的浸润性肿瘤
类似甲状腺高细胞亚型乳头状肿瘤的乳腺实性乳头状癌:一种独特的具有惰性生物学行为的浸润性肿瘤
类似甲状腺高细胞亚型乳头状肿瘤的乳腺实性乳头状癌:一种独特的具有惰性生物学行为的浸润性肿瘤
类似甲状腺高细胞亚型乳头状肿瘤的乳腺实性乳头状癌:一种独特的具有惰性生物学行为的浸润性肿瘤
类似甲状腺高细胞亚型乳头状肿瘤的乳腺实性乳头状癌:一种独特的具有惰性生物学行为的浸润性肿瘤
  来源:Am J Surg Pathol 2017;41:887–895
  美国外科病理学杂志中文版2017年第一期全文No.4
  (潘敏鸿/朱芸  翻译;张智弘 审校)
 
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